| January 24, 2021 | ||
| Osasuna | 3 - 1 | Granada |
| Deportivo Alavés | 1 - 4 | Real Madrid |
| January 23, 2021 | ||
| Real Sociedad | 2 - 2 | Real Betis |
| Sevilla | 3 - 0 | Cádiz |
| Huesca | 0 - 0 | Villarreal |
| Levante | 2 - 2 | Real Valladolid |
| January 22, 2021 | ||
| Eibar | 1 - 2 | Atlético de Madrid |
| January 21, 2021 | ||
| Valencia | 1 - 1 | Osasuna |
| Villarreal | 2 - 2 | Granada |
| Real Betis | 2 - 1 | Celta Vigo |
| January 20, 2021 | ||
| Getafe | 1 - 0 | Huesca |
| Deportivo Alavés | 1 - 2 | Sevilla |
| January 19, 2021 | ||
| Real Valladolid | 2 - 2 | Elche |
| Cádiz | 2 - 2 | Levante |
| January 13, 2021 | ||
| Atlético de Madrid | 2 - 0 | Sevilla |
| January 12, 2021 | ||
| Granada | 2 - 0 | Osasuna |
| Huesca | 0 - 2 | Real Betis |
| January 11, 2021 | ||
| Elche | 1 - 3 | Getafe |
| January 24, 2021 | ||
| Aston Villa | 2 - 0 | Newcastle United |
| January 22, 2021 | ||
| Liverpool | 0 - 1 | Burnley |
| January 21, 2021 | ||
| Fulham | 1 - 2 | Manchester United |
| January 20, 2021 | ||
| Manchester City | 2 - 0 | Aston Villa |
| Leicester City | 2 - 0 | Chelsea |
| January 19, 2021 | ||
| West Ham United | 2 - 1 | West Bromwich Albion |
| Arsenal | 3 - 0 | Newcastle United |
| January 18, 2021 | ||
| Manchester City | 4 - 0 | Crystal Palace |
| January 17, 2021 | ||
| Liverpool | 0 - 0 | Manchester United |
| Sheffield United | 1 - 3 | Tottenham Hotspur |
| Leicester City | 2 - 0 | Southampton |
| January 16, 2021 | ||
| Fulham | 0 - 1 | Chelsea |
| West Ham United | 1 - 0 | Burnley |
| Leeds United | 0 - 1 | Brighton & Hov… |
| Wolverhampton Wanderers | 2 - 3 | West Bromwich Albion |
| January 15, 2021 | ||
| Arsenal | 0 - 0 | Crystal Palace |
| January 14, 2021 | ||
| Tottenham Hotspur | 1 - 1 | Fulham |
| January 13, 2021 | ||
| Manchester City | 1 - 0 | Brighton & Hov… |
| January 24, 2021 | ||
| Juventus | 2 - 0 | Bologna |
| Fiorentina | 2 - 1 | Crotone |
| January 23, 2021 | ||
| Udinese | 0 - 0 | Inter Milan |
| Milan | 0 - 3 | Atalanta |
| Roma | 4 - 3 | Spezia |
| Benevento | 2 - 2 | Torino |
| January 20, 2021 | ||
| Udinese | 1 - 1 | Atalanta |
| January 19, 2021 | ||
| Cagliari | 0 - 2 | Milan |
| January 18, 2021 | ||
| Inter Milan | 2 - 0 | Juventus |
| January 17, 2021 | ||
| Atalanta | 0 - 0 | Genoa |
| Sassuolo | 1 - 1 | Parma |
| Crotone | 4 - 1 | Benevento |
| SSC Napoli | 6 - 0 | Fiorentina |
| Sampdoria | 2 - 1 | Udinese |
| January 16, 2021 | ||
| Torino | 0 - 0 | Spezia |
| Bologna | 1 - 0 | Hellas Verona |
| Lazio | 3 - 0 | Roma |
| January 12, 2021 | ||
| Spezia | 2 - 1 | Sampdoria |
| January 23, 2021 | ||
| Hertha BSC | 1 - 4 | Werder Bremen |
| Arminia Bielefeld | 1 - 5 | Eintracht Frankfurt |
| Augsburg 1907 | 2 - 1 | Union Berlin |
| 1. FSV Mainz 05 | 3 - 2 | RB Leipzig |
| SC Freiburg | 2 - 1 | Stuttgart |
| Bayer 04 Leverkusen | 0 - 1 | Wolfsburg |
| Borussia Mönchengladbach | 4 - 2 | Borussia Dortmund |
| January 21, 2021 | ||
| RB Leipzig | 1 - 0 | Union Berlin |
| SC Freiburg | 2 - 2 | Eintracht Frankfurt |
| Augsburg 1907 | 0 - 1 | Bayern Munich |
| Arminia Bielefeld | 3 - 0 | Stuttgart |
| January 20, 2021 | ||
| Schalke 04 | 1 - 2 | 1. FC Köln |
| 1. FSV Mainz 05 | 0 - 2 | Wolfsburg |
| Hertha BSC | 0 - 3 | TSG 1899 Hoffenheim |
| Bayer 04 Leverkusen | 2 - 1 | Borussia Dortmund |
| January 19, 2021 | ||
| Borussia Mönchengladbach | 1 - 0 | Werder Bremen |
| January 17, 2021 | ||
| Eintracht Frankfurt | 3 - 1 | Schalke 04 |
| Bayern Munich | 2 - 1 | SC Freiburg |
| January 24, 2021 | ||
| Girondins de Bordeaux | 2 - 1 | Angers SCO |
| Monaco | 3 - 1 | Olympique de Marseille |
| January 23, 2021 | ||
| Lens | 0 - 1 | OGC Nice |
| Paris Saint-Germain | 4 - 0 | Montpellier Hérault SC |
| January 21, 2021 | ||
| Olympique de Marseille | 0 - 1 | Lens |
| January 18, 2021 | ||
| Olympique Lyonnais | 0 - 1 | Metz |
| January 17, 2021 | ||
| LOSC Lille Métropole | 2 - 1 | Stade de Reims |
| Nantes | 1 - 1 | Lens |
| OGC Nice | 0 - 3 | Girondins de Bordeaux |
| Strasbourg | 1 - 0 | Saint-Etienne |
| Brest | 1 - 2 | Stade Rennais FC |
| Angers SCO | 0 - 1 | Paris Saint-Germain |
| January 16, 2021 | ||
| Olympique de Marseille | 1 - 2 | Nîmes |
| Montpellier Hérault SC | 2 - 3 | Monaco |
