| January 9, 2021 | ||
| Atlético de Madrid | 20:45 | Athletic Bilbao |
| January 24, 2021 | ||
| Elche | 20:45 | Barcelona |
| Celta Vigo | 23:00 | Eibar |
| January 25, 2021 | ||
| Atlético de Madrid | 01:30 | Valencia |
| January 26, 2021 | ||
| Athletic Bilbao | 01:30 | Getafe |
| January 30, 2021 | ||
| Real Valladolid | 01:30 | Huesca |
| Eibar | 18:30 | Sevilla |
| Real Madrid | 20:45 | Levante |
| Valencia | 23:00 | Elche |
| January 31, 2021 | ||
| Villarreal | 01:30 | Real Sociedad |
| Getafe | 18:30 | Deportivo Alavés |
| Cádiz | 20:45 | Atlético de Madrid |
| Granada | 23:00 | Celta Vigo |
| February 1, 2021 | ||
| Barcelona | 01:30 | Athletic Bilbao |
| February 2, 2021 | ||
| Real Betis | 01:30 | Osasuna |
| February 6, 2021 | ||
| Deportivo Alavés | 01:30 | Real Valladolid |
| Levante | 18:30 | Granada |
| Huesca | 20:45 | Real Madrid |
| Elche | 23:00 | Villarreal |
| February 7, 2021 | ||
| Sevilla | 01:30 | Getafe |
| December 28, 2020 | ||
| Everton | 05:30 | Manchester City |
| January 3, 2021 | ||
| Burnley | 05:30 | Fulham |
| January 13, 2021 | ||
| Aston Villa | 05:30 | Tottenham Hotspur |
| January 17, 2021 | ||
| Aston Villa | 05:30 | Everton |
| January 20, 2021 | ||
| Leeds United | 05:30 | Southampton |
| January 26, 2021 | ||
| Crystal Palace | 23:30 | West Ham United |
| Newcastle United | 23:30 | Leeds United |
| January 27, 2021 | ||
| West Bromwich Albion | 01:45 | Manchester City |
| Southampton | 01:45 | Arsenal |
| Burnley | 23:30 | Aston Villa |
| Chelsea | 23:30 | Wolverhampton Wanderers |
| January 28, 2021 | ||
| Brighton & Hov… | 01:00 | Fulham |
| Everton | 01:45 | Leicester City |
| Manchester United | 01:45 | Sheffield United |
| January 29, 2021 | ||
| Tottenham Hotspur | 01:30 | Liverpool |
| October 4, 2020 | ||
| Juventus | 23:15 | SSC Napoli |
| January 24, 2021 | ||
| Genoa | 19:30 | Cagliari |
| Hellas Verona | 19:30 | SSC Napoli |
| Lazio | 22:30 | Sassuolo |
| January 25, 2021 | ||
| Parma | 01:15 | Sampdoria |
| January 30, 2021 | ||
| Torino | 01:15 | Fiorentina |
| Bologna | 19:30 | Milan |
| Sampdoria | 22:30 | Juventus |
| January 31, 2021 | ||
| Inter Milan | 01:15 | Benevento |
| Spezia | 17:00 | Udinese |
| Cagliari | 19:30 | Sassuolo |
| Atalanta | 19:30 | Lazio |
| Crotone | 19:30 | Genoa |
| SSC Napoli | 22:30 | Parma |
| February 1, 2021 | ||
| Roma | 01:15 | Hellas Verona |
| February 6, 2021 | ||
| Milan | 01:15 | Crotone |
| Fiorentina | 01:15 | Inter Milan |
| January 24, 2021 | ||
| Schalke 04 | 20:00 | Bayern Munich |
| TSG 1899 Hoffenheim | 22:30 | 1. FC Köln |
| January 30, 2021 | ||
| Stuttgart | 01:00 | 1. FSV Mainz 05 |
| Bayern Munich | 20:00 | TSG 1899 Hoffenheim |
| Borussia Dortmund | 20:00 | Augsburg 1907 |
| Eintracht Frankfurt | 20:00 | Hertha BSC |
| Union Berlin | 20:00 | Borussia Mönchengladbach |
| Werder Bremen | 20:00 | Schalke 04 |
| RB Leipzig | 23:00 | Bayer 04 Leverkusen |
| January 31, 2021 | ||
| 1. FC Köln | 20:00 | Arminia Bielefeld |
| Wolfsburg | 22:30 | SC Freiburg |
| February 6, 2021 | ||
| Hertha BSC | 01:00 | Bayern Munich |
| Bayer 04 Leverkusen | 20:00 | Stuttgart |
| SC Freiburg | 20:00 | Borussia Dortmund |
| Schalke 04 | 20:00 | RB Leipzig |
| 1. FSV Mainz 05 | 20:00 | Union Berlin |
| Augsburg 1907 | 20:00 | Wolfsburg |
| Borussia Mönchengladbach | 23:00 | 1. FC Köln |
| February 7, 2021 | ||
| TSG 1899 Hoffenheim | 20:00 | Eintracht Frankfurt |
| Arminia Bielefeld | 22:30 | Werder Bremen |
| January 17, 2021 | ||
| Lorient | 19:30 | Dijon |
| January 24, 2021 | ||
| Stade de Reims | 19:30 | Brest |
| Dijon | 19:30 | Strasbourg |
| Nîmes | 19:30 | Lorient |
| Metz | 19:30 | Nantes |
| Stade Rennais FC | 21:30 | LOSC Lille Métropole |
| January 25, 2021 | ||
| Saint-Etienne | 01:30 | Olympique Lyonnais |
| January 30, 2021 | ||
| Olympique Lyonnais | 01:30 | Girondins de Bordeaux |
| Montpellier Hérault SC | 21:30 | Lens |
| January 31, 2021 | ||
| Olympique de Marseille | 01:30 | Stade Rennais FC |
| OGC Nice | 17:30 | Saint-Etienne |
| Angers SCO | 19:30 | Nîmes |
| Brest | 19:30 | Metz |
| Lorient | 19:30 | Paris Saint-Germain |
| Strasbourg | 19:30 | Stade de Reims |
| LOSC Lille Métropole | 21:30 | Dijon |
| February 1, 2021 | ||
| Nantes | 01:30 | Monaco |
